Encephalopathy refers to any condition that causes changes in brain function or structure. It could be caused by many things, such as infections, brain tumors, and prolonged exposure to toxic substances. The hallmark feature of encephalopathy is altered mental status, which means you become confused and don’t act like yourself.
On the other hand, encephalitis occurs when the brain is inflamed as a result of an infection or autoimmune disease. Encephalitis is diagnosed in 10 to 15 people per 100,000 each year in the United States. It can affect anyone, but is most common in younger people. Symptoms of encephalitis include headaches, stiff neck, confusion, and seizures.
Causes
Encephalopathy Causes
Numerous things can cause encephalopathy, including:
Metabolic dysfunction: Chemical imbalance in the blood that is a result of illness or organs not working as well as they should can lead to metabolic encephalopathy. Prolonged toxic exposure: Exposure to neurotoxic agents like solvents, drugs, radiation, paints, industrial chemicals, or certain metals can cause toxic encephalopathy. Repeat head trauma: Repeat traumatic brain injury can lead to chronic traumatic encephalopathy. Poor nutrition: A deficiency of thiamine, also called vitamin B1, can cause Wernicke’s encephalopathy. Lack of oxygen or blood flow to the brain: This can result in hypoxic ischemic encephalopathy.
Other conditions can also lead to encephalopathy. For example, Hashimoto’s disease, a common autoimmune thyroid disease, may lead to a form of encephalopathy called Hashimoto’s encephalopathy. Liver disease may also affect brain functioning and result in hepatic encephalopathy.
Encephalitis Causes
Possible causes of encephalitis include:
Viruses: Infections from herpes simplex viruses, enteroviruses (which cause gastrointestinal illnesses), human immunodeficiency virus (HIV), West Nile virus, and tick-borne viruses lead to viral encephalitis. This is the most common cause. Problem with the immune system: The immune system can mistakenly attack the brain, causing autoimmune encephalitis. Bacteria and parasites: These germs can cause bacterial encephalitis. An example is Lyme disease.
Symptoms
Symptoms of encephalopathy and encephalitis can range from mild to severe.
Encephalopathy Symptoms
Depending on the cause and type of encephalopathy someone has, symptoms may include:
Confusion Progressive memory loss Personality changes Inability to concentrate Lethargy Progressive loss of consciousness Myoclonus (involuntary twitching of a muscle or group of muscles) Nystagmus (rapid, involuntary eye movement) Tremor Dementia Seizures Loss of the ability to swallow or speak
Encephalitis symptoms
Encephalitis symptoms may appear gradually and are mild, but symptoms often rapidly increase and get more serious.
Common symptoms of encephalitis include:
Fever Headache Joint pain Muscle weakness Nausea Stiff neck Behavior changes Confusion Difficulty speaking or moving Loss of consciousness Memory issues Seizures Photophobia (sensitivity to light)
Diagnosis
Diagnosing encephalopathy and encephalitis is a complex process. Your healthcare providers use similar tests and evaluations to the two conditions.
Diagnosing Encephalopathy
Diagnosis of encephalopathy includes analyzing symptoms and ruling out possible other conditions with the following tools:
Physical exam Mental status exam and neurological exam Blood and urine tests Lumbar puncture (spinal tap) to test your cerebrospinal fluid Imaging, including CT and MRI of the brain Electroencephalogram, which records electrical activity in the brain
Diagnosing Encephalitis
Each part of the diagnosis process can help your doctor see signs and symptoms of an inflamed brain:
CT scan of the brain to make sure that the symptoms aren’t caused by another causeSpinal tap to look for infections, like bacteria and virusesElectroencephalogram to look for seizures An MRI to identify inflammation in the brainBlood, urine, and stool tests to check for signs of an infection
Treatment
Treatment for both encephalopathy and encephalitis is crucial to avoid worsening symptoms, complications, and even fatal outcomes.
Treating Encephalopathy
Depending on the type and symptoms, encephalopathy can be treated in a variety of ways, including medications and surgery.
Common treatments include:
Medications to alleviate symptoms, including anticonvulsants for seizuresDietary changesCognitive trainingDialysis or organ replacement surgery in people with kidney failure or liver transplant or in those with hepatic encephalopathy
Additional therapies or medications may be needed depending on the severity and complications related to your encephalopathy.
Treating Encephalitis
Depending on the type of encephalitis, treatments include:
Antibiotics to treat bacterial infectionsAntiviral medications for viral infectionsAnticonvulsants for seizures. Breathing assistance, including supplemental oxygen or a breathing machine (mechanical ventilation)Immunomodulators, which can lower immune system activitySteroids to reduce swelling and brain pressure
Prevention
Prevention of encephalopathy and encephalitis starts with knowing the causes and taking action to lower risk.
Preventing Encephalopathy
Encephalopathy isn’t always preventable, but there are risk factors and causes that you can control to lower risk. For example, staying up to date with your vaccinations and avoiding contact sports to prevent head trauma may help mitigate your risk of having encephalopathy.
Additionally, you can lower your risk by eating a balanced diet, reducing alcohol consumption, avoiding toxins, and adhering to your treatments for all pre-existing conditions.
Preventing Encephalitis
Similar to encephalopathy, you can prevent encephalitis by understanding the causes and risk factors. Avoiding the viruses that can cause encephalitis is critical. That means getting vaccinated to avoid infection, such as the measles, mumps, and rubella vaccines.
Don’t forget that bugs and animals can carry viruses, so protection against mosquitoes and ticks can also help lower your risk of getting encephalitis.
Summary
Encephalopathy and encephalitis may be different, but they are both conditions that require immediate medical attention as soon as you notice the signs and symptoms. Getting treatment early can help prevent serious long-term complications.
